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FK614 (1, 3.2 or 10 mg/kg) and a TZD PPARgamma agonist, Pioglitazone (1, 3.2 or 10 mg/kg), were orally administered to Zucker fatty rats (genetically obese and insulin resistant) once a day for 14 days, and an oral glucose tolerance test was performed. Pioglitazone, a thiazolidinedione antidiabetic drug, is metabolised mainly by the cytochrome P450 (CYP) 2C8 enzyme.

Other names for this medication:
Pioglitazone, Astrozone, Glita, Glustin, Opam, Pepar, Tiazac, Zactos,

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Pioglitazone is used with proper diet and exercise to treat high blood sugar levels caused by type 2 diabetes. It may be used alone or with other medicines such as insulin, metformin, or sulfonylurea agents. Pioglitazone works by helping your body use insulin better. This medicine does not help patients who have insulin-dependent or type 1 diabetes.

This medicine is available only with your doctor's prescription.

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The aim of the study was to observe the effect of antisense hypoxia-inducible factor 1alpha (HIF-1alpha) on progression, metastasis, and chemosensitivity of pancreatic cancer. A co-culture of clone ID and CH rodent cell lines was exposed to five successive electric pulses of about 1.5 kV/cm with a duration of 50 musec. We present a method for treating retained stones in the Radiology Department by biliary lavage via a transcystic tube (TCT) or a T-tube, after intravenous administration of glucagon. The role of convergent extension in gastrulation of other amphibians and other metazoans and its significance to related problems in early development are discussed.

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The water-prefilled PS with autoclave sterilization showed filtration and sieving properties similar to those of the nonautoclaved PS. after glucose administration in the duodenum pancreatic islet B-cells show a raised sensitivity to glucose expressed in a higher value of the insulinogenic index at this time than in later periods. Cytokeratin (CK) 5-6 is one of the most specific mesothelioma-associated antibodies. Effect of short-term exposure to five industrial metals on the embryonic and fetal development of the mouse. The main focus, however, is on a survey of psoralen photochemical modification of proteins and the ways by which these additional photobiological events can impact the antigenicity and potentially immunogenicity of treated cells.

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The results suggest that the hen pituitary LHRH receptor bindings are affected by ovarian steroid hormones and that their changes during the ovulatory cycle may relate to the release of a gonadotropin from the pituitary. DmMyD88-mutant flies were highly susceptible to infection by fungi and Gram-positive bacteria, but resisted Gram-negative bacterial infection much as did wild-type flies.

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Serum PRL showed a similar trend towards decreased values over the testing period in both groups. This recommendation is based on: (i) the prevalence of TD, predominantly hypothyroidism, (ii) the insensitivity of standard clinical assessment in detecting even overt TD, (iii) the sensitivity of a single test, serum thyroid stimulating hormone (TSH), in identifying both over- and under-function, (iv) the probable adverse consequences of failure to recognize even mild TD, (v) the safety and effectiveness of treatment, and (vi) presumed lack of adverse effect from the testing program. To determine the effect of transfusion therapy with leukocyte-depleted platelet concentrates in comparison to transfusion support with standard platelet concentrates on the frequency of HLA alloimmunization in hematologic-oncologic patients. This means that quercetin probably does have a broad modulatory effect on gene expression in colon cancer. Glycinebetaine (hereafter referred to as betaine) is a compatible solute that accumulates in certain plants and microorganisms in response to various types of stress.

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When a stimulus was applied to all fibres of the cutaneous nerve, the action potentials with conduction velocities of 146-0.24 m/s were recorded in dorsal columns. In addition, our results suggest that the amino-terminal regulatory region of Raf inhibits the interaction. The formation of 19S antibody to poliovirus by rabbit spleen cells in vitro was interrupted by adding actinomycin D (1 to 10 micrograms per milliliter) for 30 minutes or longer. It was labeled most strongly 4 hours after adding ornithine-2-(14)C to the root, also labeled by putrescine-1,4-(14)C and methionine-(14)CH(3), and observed in the root but not in the aerial portions of tobacco plants.

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Dopamine, 1-10 micrograms/kg body weight/min was infused in 6 patients suffering from cerebrovascular diseases with elevated intracranial pressure and a critical cerebral perfusion pressure. A major CD4 binding site encompassing amino acids 134-148 in the beta 2 domain of HLA-DR has been previously identified. Recent studies suggested that B-Raf could be the intermediate molecule between Ras and Mek-1 (MAP Kinase Kinase) in signalling pathways specific of neural cells. Metabolic and energy balance in small- and appropriate-for-gestational-age, very low-birth-weight infants.

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Relationship between insulin resistance and coronary heart disease in diabetes mellitus and the general population: a critical appraisal. Improved factor Xa cleavage of fusion proteins containing maltose binding protein. Two rare cases with histologically proven multiple primary neoplasms are described: an association of intracerebral malignant lymphoma with hepatocellular carcinoma in one case and with squamous cell carcinoma of the uterine cervix in the other. Although several genes related to FHB resistance have been reported, global analysis of gene expression in response to FHB infection remains to be explored.

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Hepatectomy in patients with advanced hepatocellular carcinoma after hepatic artery chemotherapy/embolization or hepatic artery embolization/ligation Halichondramine, a new tetracyclic bipiperidine alkaloid from the marine sponge Halichondria sp. Inactivation of either the bdbC or bdbD genes of this operon results in the loss of transformability without affecting recombination or the synthesis of ComK, the competence transcription factor.

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Development of the integrated general practitioner training scheme in orthodontics. The rapid diagnosis of suspected human rabies cases influences the use of anti-rabies post-exposure prophylaxis for potential contacts with the victim. Degree of leucine utilization in the provision of substrate for lipid synthesis in animal tissues in vivo Comparison of lactate or BE during out-of-hospital cardiac arrest to determine metabolic acidosis. Within each age group, 3 animals underwent no surgery, 3 underwent perichondrial injury, and 3 underwent intracartilaginous injury.

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Daily gain adjusted to mean daily feed intake increased linearly with inclusion rate of STG, indicating that the weight gain was affected by both feed intake and the enhancing effect on digestibility of STG. Middle-term results for patients transplanted for viral C related liver cirrhosis are good, but the recurrence rate of HCV infection is high. Secondary osteonecrosis was found by pathologic examination in nine (6 per cent) of 150 femoral heads removed surgically for osteoarthritis. During an intravenous glucose tolerance test, the rate of glucose disappearance was higher in Mg 100 rats than in controls. The effect of R-PIA was prevented by 8-phenyl-theophylline, confirming the involvement of a purine P1 receptor.

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Identification and Estimation of Catabolic Pathways of Glucose in Fruits. Several non-viral techniques involving the use of liposomes, particle bombardment and electroporation have been used for efficient transfection of plasmids and other molecules into cells. N-cadherin is a major glycoprotein component of isolated rat forebrain postsynaptic densities.

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Rivulus marmoratus mitochondrial DNA also has two nearly identical control regions. We also investigated the effect of insulin (50 and 100 microU/ml) in the diabetic mesenteric vascular beds, but there were no changes in prostaglandin or TxB2 release.

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Mean quantity of labelled neurons per 50 micron slice was regarded as a measure of density. Site directed mutagenesis allowed to establish that both domains bear in fact a functional active site, able to convert angiotensin I into angiotensin II and to hydrolyze bradykinin or substance P. Performing major upper abdominal operations in a low-volume hospital: is it possible? At present, however, nothing is known about molecules which may regulate the biological activity of BMP-15.

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Small bowel perforation with minor trauma: a rare complication of an ovarian cystic teratoma. Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver. Alterations of primary VEP components in the cortical blindness induced by a perinatal encephalopathy.

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Prevalence and risk factors of non-insulin-dependent diabetes mellitus in the rural and urban population of Tunisia One of these transfers most likely occurred between a prokaryote and an ancestor of diplomonad protists. Similarities in the detection of stimulus symmetry by individuals with and without mental retardation. The teaching of anatomic pathology in England and Wales: a transatlantic view. The ANA seeks investment in nursing workforce development: safe patient handling and staffing at the forefront.

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Schisis-like rhegmatogenous retinal detachment associated with choroidal colobomas. Mouse embryonic stem (ES) cells cultured as aggregates and exposed to retinoic acid are induced to express multiple phenotypes normally associated with neurons. The aim of this review is to provide current knowledge on epithelial-mesenchymal interactions during ontogenesis of the digestive tract and also to relate some experiments supporting the view of the perpetuation of epithelial-mesenchymal interactions beyond embryonic life. Tissue Doppler imaging (TDI) has evolved to become a useful noninvasive method that can complement other echocardiographic techniques in the assessment of left ventricular myocardial velocities in a variety of clinical conditions.

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Environmental policy-making has become more dependent on formal, quantitative risk assessment because of increasing attention to the prevention of human health damage from toxic chemicals. Synthesis of deacetyl-thymosin beta 12 and examination of its immunological effects on the impaired T and B lymphocytes in biaxin xl clarithromycin extended release tablets uremic patients.

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Under highly stringent conditions the gene coding for the pI 8.6 beta-lactamase hybridised with chromosomal DNA from Citrobacter freundii OS60 but not from E. Continued deterioration of anionic sites and possibly additional disturbance of size barrier were considered responsible for the development of albuminuria. A similar staining was found with 7 out of 52 other unselected IgM paraproteinaemias. A new technique is described for regional perfusion chemotherapy in the presence of a replaced right hepatic artery. No additive or bimoxyl la injection letale synergistic effect was observed when astrocytes were exposed to both peptides.

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Liver transplantation in pigs: a model for studying reperfusion injury. Review of Corynebacterium (Rhodococcus) equi lung abscesses in foals: pathogenesis, diagnosis and treatment. With all of these interventions there was a close correlation between intracellular calcium (systolic, diastolic, and helicid forte ulotka amplitude) and oxygen consumption or left ventricular developed pressure. Both features may provide additional stimulus to the immune response directed against novel antigens, such as those delivered by gene therapy vectors. Keratinocyte dysplasia: an usual finding after transplantation or chemotherapy.