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Aklovir (Acyclovir)
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Acyclovir

Aklovir is an antiviral drug, a synthetic nucleoside analogue, that has inhibitory activity (interferes with viral replication) against the herpes viruses, including herpes simplex 1 and 2 (cold sores and genital herpes), varicella-zoster (shingles and chickenpox), and Epstein-Barr virus (mononucleosis). Viruses take over living cells and reproduce themselves, often at the expense of the host cell. The Aklovir is converted to an active form by the virus itself, and the virus then uses the active form of Aklovir rather than the nucleoside it normally uses to manufacture DNA, a critical component of viral replication. Incorporation of active Aklovir into new viral DNA stops the production of the DNA. Virally infected cells absorb more Aklovir than normal cells and convert more of it to the active form, which prolongs its antiviral activity. The FDA approved Aklovir in March 1982.

Other names for this medication:
Acyclovir, Abduce, Acic, Aciclobeta, Aciclomed, Aciclostad, Aciclovirum, Acifar, Acihexal, Aciklovir, Acitop, Acivir, Acivirex, Acivision, Acix, Actios, Activir, Acycloguanosine, Acyl, Acyrax, Acyvir, Aklovir, Antivir, Asiviral, Avir, Aviral, Avix, Avorax, Blistex, Cicloferon, Cicloviral, Clinovir, Clirbest, Clopes, Clovate, Clovir, Cusiviral, Cyclomed, Cyclovax, Cyclovex, Cyclovir, Danovir, Declovir, Epsin, Eurovir, Hascovir, Hernovir, Herperax, Herpesil, Herpesin, Herpex, Herpin, Herplex, Heviran, Immunovir, Lisovyr, Lovir, Lovire, Lovrak, Medovir, Menova, Ocuvir, Poviral, Ranvir, Remex, Rexan, Scanovir, Sitavig, Sophivir, Soviclor, Supraviran, Telviran, Uniplex, Vilerm, Viraban, Viralex, Viratac, Viratop, Virest, Virestat, Virex, Virless, Viroclear, Virolex, Viromed, Virosil, Virostatic, Virovir, Virucid, Viruderm, Virustat, Virux, Vivorax, Xiclovir, Xorox, Zevin, Ziverone, Zoral, Zorax, Zoraxin, Zovirax,

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Aklovir is also sometimes used to treat eczema herpeticum (a skin infection caused by the herpes virus) to treat and prevent herpes infections of the skin, eyes, nose, and mouth in patients with human immunodeficiency virus (HIV), and to treat oral hairy leukoplakia (condition that causes hairy white or gray-colored patches on the tongue or inside of the cheek).

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

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The most important pathway for the catabolism and excretion of cholesterol in mammals is the formation of bile acids. Surprisingly, there were no significant differences in the levels of the oxidation products in the ascorbate-deficient and -replete Gulo(-/-)mice.

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These results confirm that ethanol-related dilation of SER profiles in PN dendritic shafts occurs following the same duration of treatment as the dendritic regression previously reported in other studies. Glomerulonephritis associated with MRSA infection: a possible role of bacterial superantigen. We present a case of atrophy of the masticatory muscles due to a masticatory habit.

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This strain allowed the transfer of functional CFTR to CHO-K1 cells. It appears that hypoxia synergizes with LPS in the induction of M phi TNF-alpha production through PDE-mediated cAMP degradation. To investigate the significance of the isoleucine-proline (residues 2427-2428) dipeptide epitope, which is thought to form an essential part of the FKBP12.6 binding site in RyR2, we generated single and double mutants, P2428Q, I2427E/P2428A, and P2428A/L2429E, expressed them in HEK293 cells, and assessed their ability to bind GST-FKBP12.6. The LPN track facilitated the achievement of the associate degree or baccalaureate degree through curricular options which decreased the length of time and/or credit load for the LPN. We studied three unanswered questions regarding MPO biosynthesis: (1) At what point during MPO biosynthesis is the heme moiety inserted into the apoenzyme?

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The use of a scanning delay at CT prior to imaging the pelvis showed extravasation of IV contrast material in all seven children with bladder rupture. Comparison of the side effects and gastrointestinal motility observed after administration of erythromycin and josamycin to dogs. Rectoromanoscopic findings during prophylactic examination of peptic ulcer patients We explicitly study the homogeneous Semenov model involving a thermochemical reaction and neglecting consumption of reactants. The initial rate of SO3.- radical formation increases linearly with xanthine oxidase concentration.

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Surveys conducted in several countries corroborate the wellknown fact that a large proportion of old-age people take drugs (frequently different types at the same time). It has been proposed that this recombination converts chromosome multimers formed by homologous recombination back to monomers in order that they can be segregated prior to cell division.

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These results suggest that the peripheral autonomic nervous system is involved in the mechanism of emesis induction by cisplatin. Aseptic cerebral venus thrombosis is an infrecuent condition that often is cause of neurologic complications that may become severe. It is suggested that CO(2) delays fruit ripening by displacing the ripening hormone, ethylene, from its receptor site.

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Deuterium isotope effects on the rates of steroid--glucocorticoid receptor interactions. Multicomponent ointments with hydrophilic bases for the treatment of purulent wounds Adjacent binding sites for NF-Y and Sp1 have also been found between -71 and -52, and -91 and -83.

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Physician assisted suicide and voluntary euthanasia: some relevant differences. When sonography was inconclusive, CT amniography confirmed a single amniotic cavity, permitting appropriate parental counseling and pregnancy management.

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Two unusual patients with chronic, undifferentiated schizophrenia committed acts of ocular self-mutilation. Three-dimensional structures have been determined of a large number of proteins characterized by a repetitive fold where each of the repeats (coils) supplies a strand to one or more parallel beta-sheets. pombe total protein extract relied on base excision repair and not nucleotide excision repair.

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AG had inhibitory effect on pulmonary injury and fibrosis induced by BLM-A5, and the inhibitory effect was related to the decrease of NO production in lung. Sensitive procedures for measuring chloride fluxes mediated by the purified glycine receptor incorporated into phospholipid vesicles. All the donor sites were closed primarily, and desquamation of wound edges occurred occasionally.

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4-Keto niridazole: a major niridazole metabolite with central nervous system toxicity different than niridazole. However, some oils, at concentrations as low as 25 ppm in recovery media, reduced populations of sublethally heat-stressed cells compared to populations recovered in media containing no test oils. This restoration was not found in nonresponders or acutely after treatment was commenced. The binding of a further 25 drugs to rat liver microsomes at a microsomal concentration of 1 mg/ml was also studied, along with measurements of lipophilicity using octanol-water partition coefficients.

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The beta gamma-mediated membrane localization of beta ARK serves to intimately link receptor activation to beta ARK-mediated desensitization. Two Polypeptides in the Inner Chloroplast Envelope of Dunaliella tertiolecta Induced by Low CO(2). CB3717 retains activity against transport-defective MTX-resistant cells, and also against cells that overproduce DHFR. These findings strongly suggest that the HIV-1 MA domain of HIV-1 Gag is responsible for the assembly defect in mouse cells. The beam-walking task and the Lashley maze are robust and sensitive methods in detecting sensorimotor and cognitive impairment after TBI in rats, respectively.

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A region of feline immunodeficiency virus (FIV)/Glasgow-8 external envelope glycoprotein (env) incorporating the third and fourth variable regions (V3/V4) was cloned, inserted into the pGEX vector and expressed in Escherichia coli to yield milligram quantities of the recombinant polypeptide as a fusion protein with glutathione S-transferase. Inhibition of N-nitrosodimethylamine metabolism by ethanol and other inhibitors in the isolated perfused rat liver. In stromal dystrophies, PTK was effective in removing large subepithelial stromal plaques.

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The ACE molecule is organized into two large highly homologous domains, each bearing consensus sequences for zinc binding in metallopeptidases. Eighty-four cases were randomly divided into a treatment group of 46 cases and a control group of 38 cases. The demonstration of vasculitis and anti-myeloperoxidase antibodies in the mercuric chloride treated Brown Norway rat provides a useful, though limited, animal model of systemic vasculitis. The main objective of this study was to produce angiographic evidence of basilar artery constriction using the rabbit model. Eritrea has within 5 years attained key Roll Back Malaria targets.

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Its reduction by the combined administration of superoxide dismutase and catalase. The effect of beta-aescin, a saponin, on prenatal development in mice

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Cloning, expression and characterisation of the cDNA encoding human hepatic squalene synthase, and its relationship to phytoene synthase. This 10-session program improved important elements of residency education and was favorably received. Withdrawal from nicotine Increased DBI mRNA expression in cerebral cortices derived from nicotine-dependent mice and in the neurons continuously exposed to nicotine (0.1 microM). To compare effects of an early intervention program (EIP) of intense home visitation by public health nurses (PHNs) with effects of traditional public health nursing care (TPHN) on infant health and selected maternal outcomes of adolescent mothers.

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Quercetin is a flavonoid and widely used as an antioxidant and recent studies have revealed its pleiotropic anticancer and antiproliferative capabilities. Designing a process to use patient input in performance improvement requires reviewing the patient groups served by the organization, the important clinical and organizational functions that affect patients, the dimensions of performance that affect patients in each function, and the possible methods for gathering and using patient input. Lengthening procedures are often complicated by loosening of pins.

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Reverse-transcription PCR followed by Southern-blot analysis using specific oligonucleotide probes showed expression of tissue kallikrein in human colon, pancreas and kidney. Although Type 2 congenital kyphosis is a rare entity, it should be followed carefully and corrected surgically when appropriate. Less subject to misunderstanding is Paragraph 1 of the German Law Book, which refers to the legal rights of human beings from the completion of birth, specifying only the live born and not the still-born. Early diagnosis and aggressive treatment is essential in order to improve prognosis. It shows selectivity for soluble and lipid substrates having a 1,4,5-trisphosphate substitution pattern while only poorly hydrolyzing substrates containing a D3 phosphate.

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A method for the quantitative analysis of N-oxalylcysteine and oxalyl thiolesters (RSCOCOO-) in biological samples is described. This basic property affects their digestion, absorption, and transport in the blood and metabolism at cellular level.

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The results also suggest that, if the tip links are indeed involved in transduction, some degree of stimulus transduction can continue in damaged inner hair cells, albeit with a reduced sensitivity. Migration of cranial neural crest cells to the pharyngeal arches and heart in rat embryos. Using cultured fetal lung explants, it has been reported that dexamethasone (Dex) increases FAS activity, protein content, mRNA content and rate of transcription.

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These lesions were indeterminate on clinical and mammographic examination. Postoperative unprovoked serum calcitonin assays have been performed. Direct anti-inflammatory effects seem to be more important than the weak immunosuppressive properties.

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Among them, the key role belongs to the family of cystein proteases--caspases activated either through the death receptors or via activation steps starting with the release of a mitochondrial cytochrome c. Gap-junctional single-channel permeability for fluorescent tracers in mammalian cell cultures.

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Morbidity rate in each group was 14.3 per cent (EC) and 27.9 per cent (IC) respectively. Addition of UQ(0) to HbO(2) resulted in the immediate detection of a five-line ESR spectrum characteristic of the semiquinone radical of UQ(0) (UQ(0)). faecalis strains were found in different root-filled teeth from the same mouth. Combined radiation and clarimax 500 mg indicaciones geograficas chemotherapy in anal carcinoma: preliminary results.

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