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Long-term efficacy and safety of modafinil (Alertec((R))) for the treatment of excessive daytime sleepiness associated with narcolepsy. We assessed prescription patterns for four top-selling orphan drugs: lidocaine patch (Lidoderm) approved for post-herpetic neuralgia, modafinil (Alertec) approved for narcolepsy, cinacalcet (Sensipar) approved for hypercalcemia of parathyroid carcinoma, and imatinib (Gleevec) approved for chronic myelogenous leukemia and gastrointestinal stromal tumor.

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Provigil, Modafinil, Renea, Modatec, Modapro, Alertec, Modavigil, Modiodal, Modafinilo, Carim, Vigia,

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Alertec is prescribed for people who suffer from sleep disorders or narcolepsy - a pathological sleepiness associated with brain disorders. The active component of Alertec is Modafinil. Researches have shown numerous advantages of using Modafinil as a stimulator in comparison with amphetamines. Alertec doesn't cause addiction syndrome, it almost does not cause euphoria, reduces the peripheral nervous system tension and has very small effect on blood pressure.

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Whereas addition of 200 ng ml-1 exotoxin A (exoA) did not modify PMNL chemotaxis, 20 U ml-1 human recombinant interleukin-1 beta (hrIL-1 beta) primed polymorphonuclear leukocytes (PMNL) for migration towards Pseudomonas aeruginosa peptide chemotactins (PAPCs). From this incidence and other several factors, the author concluded that the incidence of scoliosis in Japan increased recently.

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DETERMINATION OF THE DIFFUSION CAPACITY OF THE LUNG WITH AID OF CARBON MONOXIDE (SINGLE RESPIRATION METHOD) IN CHRONIC LUNG DISEASES Axisymmetric shapes and forces resulting from the interaction of a particle with a solidifying interface.

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Failure of doxycycline as a causal prophylactic agent against Plasmodium falciparum malaria in healthy nonimmune volunteers. Assessing genetic stability of a recombinant protein at the nucleic acid level.

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Similar regulation of cell surface human T-cell leukemia virus type 1 (HTLV-1) surface binding proteins in cells highly and poorly transduced by HTLV-1-pseudotyped virions. Heterophilic antibody interference with CARDIAC T Quantitative Rapid Assay. Trypanosoma cruzi: variable fusogenic ability by different growth phases of the epimastigote form. The Stille coupling reaction of 18 with vinylstannane, followed by cleavage of MOM ether, afforded the 1-ethenyl-3-hydroxymethyl-beta-carboline (7a). Data on establishing the maximum permissible concentration of ammonia in the gaseous medium of insulating materials for individual protection

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Gain-of-function mutations of fem-3, a sex-determination gene in Caenorhabditis elegans. Furthermore, when the TrkB tyrosine kinase was blocked with the Trk-specific inhibitor CEP-2563, or by neutralizing antibody to BDNF, sensitivity to chemotherapy was significantly increased.

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A 46-year-old woman with giant chondrosarcoma of the sternum underwent wide full-thickness resection of the anterior chest wall, which included the pericardium and lung. Real-time computing without stable states: a new framework for neural computation based on perturbations. Sixteen of these patients were also examined with SPECT imaging with thallium-201. The major new conclusions are that: the onset of dynamic exercise does not produce mass, uniform sympathetic discharge in humans, and muscle chemoreflexes and central command appear to produce differential effects on sympathetic and parasympathetic responses.

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Proceedings of the Workshop on Neurobehavioral Effects of Solvents. During hospitalization in criminal mental hospital, the presuppositions to reinstate the patient in his original environment are created by the use of cognitive and ludo-ergo-therapy. Terminal transferase-dependent PCR (TDPCR) is a versatile, sensitive method for detecting DNA lesions such as those generated by the footprinting agents commonly used to detect in vivo protein-DNA interactions. Effect of heparin concentration and infusion rate on the patency of arterial catheters.

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Isolation and characterization of YlBEM1, a gene required for cell polarization and differentiation in the dimorphic yeast Yarrowia lipolytica. The activity of latent insulin-glucagon protease associated with low-density vesicles is sufficient to account for the rate of intravesicular proteolysis. Fatty streak initiation in Watanabe Heritable Hyperlipemic and comparably hypercholesterolemic fat-fed rabbits. Swallow syncope in association with Schatzki ring and hypertensive esophageal peristalsis: report of three cases and review of the literature. THE RELATION BETWEEN MELATONIN, A PINEAL SUBSTANCE, AND THE EFFECTS OF LIGHT ON THE RAT GONAD.

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We have devised an assay in which the human progesterone receptor translated in vitro binds to its specific response element in a hormone-dependent manner. Interactions between Escherichia coli nucleoside-diphosphate kinase and DNA.

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We believe it is important that a treatment plan for Chiari I malformation accompanied by bony anomaly of the craniovertebral junction be determined based on morphologic investigation of the region supplemented by dynamic imaging-based evaluation of instability, or a careful inspection for atypical passage of the vertebral arteries, a frequent site of complication. The objective was to determine whether caffeine explains the homocysteine-raising effect of coffee. Apiosporamide, a new antifungal agent from the coprophilous fungus Apiospora montagnei.

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Endogenous catecholamines upregulate alveolar fluid clearance in several experimental models of acute lung injury, but this upregulation may be short term and insufficient to counterbalance alveolar flooding. To describe the epidemiology of mental problems in general practice, from the viewpoint of the general practitioner (GP). Our results reveal a crucial role of Nrf-mediated gene expression in keratinocytes in the prevention of skin tumors and suggest that activation of Nrf2 in keratinocytes is a promising strategy to prevent carcinogenesis of this highly exposed organ. This exhibits kinetic properties similar to type 2A protein phosphatases, but has a distinctly lower sensitivity towards inhibition by okadaic acid (IC50 approx. Congenital absence of the pericardium: echocardiography as a diagnostic tool.

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After ischemia and reperfusion, hearts from control- and alcohol-fed animals that were nonseptic showed significantly decreased left ventricular performance. This rise appears to be independent of the number of surgical treatments, the immigration rate, and the Chernobyl fallout as the incidence of TC in children remained stable.

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Traffic flow can be understood as a realization of a broad class of one dimensional physical systems, where a hard core repulsive interaction competes with a longer ranged attraction between the particles. A 6 week culture in a CO2-enriched medium is recommended for growing Brucella. By SDS-PAGE analysis, the two proteins had molecular weights of 75 and 55 kD. While there is no evidence of association within our MS sample with either of these polymorphisms, screening of 1027 subjects with SLE suggests that IBD5(risk) may have a modest contribution to disease risk in the subset of SLE subjects without lupus nephritis. Proteolytic activation of bacterial toxins: role of bacterial and host cell proteases.

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This conserved component of several retroviral envelope proteins, CKS-17, may act as an immunomodulatory epitope responsible for cytokine dysregulation that leads to suppression of cellular immunity. Among these dHMN-VII and HMSN-IIC are clinically similar but are differentiated by sensory involvement in HMSN-IIC. Expression in the cortex in response to LH and FSH may be due to their gonadotropic effect on testosterone production.

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Many results from literature as well as our data give strong support in demonstrating that PS is involved in all four stages of the CM. Effect of a dietary fiber (beet fiber) on dimethylhydrazine-induced colon cancer in Wistar rats.

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We performed a single-unit, retrospective study analyzing 36 patients who underwent resectional surgery for Klatskin tumor. It demonstrates that seizure recurrence can increase with longer duration of follow-up. We report a patient with unusual high grade dermatofibrosarcoma protuberans, confirmed by immunohistochemistry, which developed at radiotherapy field margins 5.7 years after radiotherapy for a squamous cell glottic cancer. Stable transfection of a mutant IkappaBalpha lacking Ser(32) and Ser(36) that was insensitive to IKK-mediated phosphorylation and degradation resulted in reduced sensitivity of tumor cells to paclitaxel-induced apoptosis.

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His symptoms progressively increased over 14 years, with 11 relapses of similar episodes. With discovery of injury to one hemidiaphragm, injury to the opposite side should be excluded. Earlier monitoring of all symptoms, hospital admissions, cancer diagnoses and causes of death during gemfibrozil treatment had raised some suspicions which called for further follow-up. An abnormal airway was significantly more likely after a high-velocity injury, and when the tongue, floor of mouth, midline or bilateral facial skeletal bones were involved.

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However, in carnivorous mammals a restricted feeding regime could act as a zeitgeber because the predator should hold a periodism correlated to that of the prey. We suggest that this combination of techniques might prove useful for the simultaneous assessment of the expression of various cytokines from small samples of fresh human epidermal cells. Isolation of a homodimeric lectin with antifungal and antiviral activities from red kidney bean (Phaseolus vulgaris) seeds.

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We report the successful combined use of tissue expansion and microsurgical free tissue transplantation to reconstruct a patient with RDEB found to have malignancy of the hand. Three blood group A active glycolipids with four, six and seven sugars were found in both rat strains, with sequences analogous to the B glycolipids but with a terminal GalNAc instead of Gal. In particular, increasing or decreasing pH from 7.0, results in a decrease of the extinction coefficient and of the ellipticity in the Soret region and in a change of the shape of the electron paramagnetic resonance signal.

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Fluorescence resonance energy transfer (FRET) is widely used in biomedical research as a reporter method. Players and coaches have recognized the important role of science in supporting tennis training and development. The critical role of geometry of porous hydroxyapatite delivery system in induction of bone by osteogenin, a bone morphogenetic protein. Intraperitoneal hemorrhage following femoral artery cannulation for intraoperative monitoring: an unusual complication.

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We examined the effects of mixtures of cytokines on gene expression by CNS glial cells, as mixtures of cytokines are present in MS lesions, which in turn contain mixtures of glial cells. Pathogenesis and control of infectious diseases caused by factors in animal production

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STAT-1 production was restored and detectable in FLMT cells treated with a proteosome inhibitor, such as MG132 or lactacystin. Pulsatile release tablets containing 60 mg DIL with 4.4 h of lag time (t10) in vitro were administrated to eight volunteers. Effect of resveratrol on nitrate tolerance in isolated human internal mammary artery. Nuclear staining was seen in 1 superficial tumour and in 13 invasive tumours. Additionally, individuals with higher Jenkins Activity scores (characteristic of the Type A behavior pattern) perform better physically.

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Effect of dietary electrolytes upon calcium excretion: the Yi People Study. Indomethacin pretreatment caused an apparent dose-related increase in pressor responses in all animals.

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The capability to induce an adaptive response by low doses of busulfan (BS) or adriamycin (ADR) was studied in two kinds of mammalian cells with acquired or inherent resistance to ADR (ME18/R and V3) cultured in vitro. A stratified, multiple-staged sampling design was used to select study areas, in which household interviews were carried out to gather information on health status and 24-h food recall. These data suggest that in the absence of LH-RH agonist use 3-D conformal radiation therapy and transperineal prostate brachytherapy have a similar impact on erectile function and overall satisfaction.

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Ontogeny of beta-adrenergic receptors in pulmonary arterial smooth muscle, bronchial smooth muscle, and alveolar lining cells in the rat. Limb deficiencies, chorion villus sampling, and advanced maternal age. RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins. At laparotomy, however, there was complete necrosis of the pancreatic head.

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Electrophoretic, biosensor, and bioactivity analyses of perlecans of different cellular origins. 5-lipoxygenase: structure and stability of recombinant enzyme, regulation in Mono Mac 6 cells. Case report: radiation-induced vasculopathy implicated by depressed blood flow and metabolism in a pineal glioma.

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On presentation, the bird was slightly obtunded, seizured once for approximately 20 sec and the seizure was controlled with midazolam. Relationships between structure and interaction kinetics for HIV-1 protease inhibitors.

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In Drosophila melanogaster males, X-Y meiotic chromosome pairing is mediated by the nucleolus organizers (NOs) which are located in the X heterochromatin (Xh) and near the Y centromere. When ANP is microinjected into the cerebroventricle or nucleus tractus solitarii, it causes inhibition of sympathetic nerve activity. Coronary blood flow, which increases in response to exercise (endogenous sympathetic stimulation) however, is decreased by cocaine intake. Insertions of the SMRV-H genome were seen in all Namalwa cell lines tested, with multiple insertions being seen in some sublines.

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Stable association between the bovine papillomavirus E5 transforming protein and activated platelet-derived growth factor receptor in transformed mouse cells. Twenty four in-patients with an endogenous or non endogenous depressive syndrome (9 and 15, respectively) were treated in hospital for 21 days with various dosages regimens of clomipramine. Response of chronic experimental cerebral vasospasm to methylprednisolone and dexamethasone. Moreover, minimal amounts of general (mean or range of populations) or specific (1 or 3 countries) information made available for inspection while estimating produced a significant seeding effect. The neural mechanisms responsible for the timing and induction of photorefractoriness by this seasonal clock are unknown.

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The CMVm promoter expressed luciferase much earlier, and although it expressed a bit less than did the p10 promoter, the CMVm promoter gave rise to greater luciferase activity. Passively acquired autoimmunity and the maternal fetal dyad in systemic lupus erythematosus. Decreased torque and electromyographic activity in the extensor thigh muscles in chondromalacia patellae. UV-induced DNA incision and proliferating cell nuclear antigen recruitment to repair sites occur independently of p53-replication protein A interaction in p53 wild type and mutant ovarian carcinoma cells. Stress induces an imbalance of neuroimmunomodulation, a phenomenon involving the immune, central nervous and endocrine systems.

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Perineal and anal sphincter trauma, and deteriorating anal continence after delivery. Under the same conditions, reduced beta2M did not form typical amyloid fibrils, although it inhibited fibril extension competitively, suggesting that the conformation defined by the disulfide bond is important for amyloid fibril formation of beta2M. Neonatal lupus erythematosus: discordant disease expression of U1RNP-positive antibodies in fraternal twins--is this a subset of neonatal lupus erythematosus or a new distinct syndrome? Serum urate levels and urinary uric acid excretion in subjects with metabolic syndrome An ultrasensitive tumor enriched flow-cytometric assay for detection of isolated tumor cells in bone marrow of patients with breast cancer.

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Structural integrity of the nuclear matrix: differential effects of thiol agents and metal chelators. In a multicenter trial comparing secondary prophylaxis with vitamin K antagonists for 6 weeks or 6 months, we extended the originally planned 2 years follow-up to 10 years. The remainder required specific therapy with vancomycin, bacitracin, or metronidazole. Easily administered, inexpensive field tests of fitness are available.

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A comparison of the efficacy and cost-effectiveness of two methods of managing pressure ulcers. Sixty-two per cent of the patients in the group that deposited autologous blood did not receive additional homologous blood while in the hospital. Previous small uncontrolled studies suggested that fludrocortisone may significantly decrease serum potassium concentrations in hemodialysis patients, possibly through enhancement of colonic potassium secretion. Intravenous 16 mg of lornoxicam with 10 mg of morphine significantly reduced postoperative pain during the first 6 h after abdominal hysterectomy.

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The macronuclear gamma-tubulin-encoding gene of Euplotes octocarinatus contains two introns and an in-frame TGA. We report two cases of fundic endocrine tumors associated with fundic atrophic gastritis-related hypergastrinemia and treated by antrectomy. Simazine treatment (0.00, 0.03, 0.08, 0.12 milligrams per liter) resulted in no significant stimulatory or inhibitory effects at low temperatures, but progressively inhibited growth and photosynthesis at the higher temperatures. In a recent study, we have shown that GroEL interacts preferentially with the side chains of hydrophobic amino acids (Ile, Phe, Val, Leu, and Trp) and more weakly with several polar or charged amino acids, including the strongest alpha-helix and beta-sheet formers (Glu, Gln, His, Thr, and Tyr). The stapled anastomosis required significantly shorter time (p less than 0.01), and had significantly greater tensile strength (p less than 0.05) when compared with manual anastomosis.

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In this article, the forms of viral keratitis most commonly encountered by the clinician are reviewed. Analysis of Schwann cell adhesion and spreading on dishes coated with various type V collagen domains revealed that Schwann cells adhered effectively only to the advilcaps 200 mg capsule molle non-collagenous N-terminal domain (NTD) of the alpha4(V) collagen chain. THE EFFECTS OF ESTRADIOL ON ACID MUCOPOLYSACCHARIDE METABOLISM IN OOPHORECTOMIZED RATS. HPN is a lifesaving therapy but has severe consequences on daily life.

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A prospective, longitudinal study with a 1-year follow-up was designed. The second case suggests that muromonab-CD3 encephalopathy predisposes patients to develop cyclosporin neurotoxicity. Condom characteristics: the perceptions and preferences of men in the United States. Heart valve disease is chemists own cold eeze tablets an important cause of morbidity and mortality worldwide.

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Neuroglobin (Ngb) is a recently discovered monomeric globin with high affinity for oxygen and preferential localization to vertebrate brain. Although no statistically significant differences were found in this study, several trends were identified. For coronary interventions, 1 program was a persistent outlier for mortality in 2002 and 2003. Furthermore, tyrosine hydroxylase immunoreactivity was up-regulated both by sound conditioning alone, and by oxybutynin brand name in pakistan most people the combined treatment of sound conditioning and acoustic trauma.

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Theophylline metabolism in healthy nonsmokers and in patients with amlodipine and valsartan tablets cvs caremark insulin-dependent diabetes mellitus. Given a choice between alternating lanes of embryonic (E18-19) and neonatal (P0-1) rat cortical plate membranes, embryonic (E18-19) thalamic and cortical neurites prefer to extend on neonatal membranes.

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A suitable combination of synthetic design, orthogonal protecting groups and coupling reagents was used to complete the first known synthesis of the natural marine cyclodepsipeptide IB-01212. Short wavelength collective dynamics in phospholipid bilayers: a molecular dynamics study. Collective properties of neural networks: a statistical physics approach. Intraoperative and early postoperative chemotherapy into the abdominal cavity using gemcitabine may prevent postoperative occurence of peritoneal carcinomatosis. Corresponding to the effect on IOP, 0.2 micrograms, 2 micrograms, and 20 micrograms sulprostone decreased the norepinephrine (NE) concentration tadalafil effective dose of melatonin in the aqueous humor in the dark phase.