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Calaptin (Verapamil)

Why does the inner-helix mutation A413C double the stoichiometry of Kv1.3 channel block by emopamil but not by Calaptin? Centrally administered Calaptin prevents the autonomic reaction to visceral pain in sheep. Temporary pacemaker in refractory cluster headache treated with Calaptin.

Other names for this medication:
Verapamil, Calan, Calaptin, Isoptin, Verelan,

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Calaptin is used alone or together with other medicines to treat heart rhythm problems, severe chest pain (angina), or high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Calaptin is a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. As a result, Calaptin relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Tablet
  • Tablet, Extended Release
  • Capsule, Extended Release

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Therefore, we believe that a trial of thick catheter percutaneous drainage of retroperitoneal abscess, without a complex septum, should be the initial mode of therapy, and surgical intervention should be undertaken only when percutaneous drainage fails or is contraindicated. These ligands conferred to the human progesterone receptor (hPR) only weak activation properties despite high affinity binding and, hence, acted as agonists and, at the same time, as partial antagonists of pure agonists. Insertion of Groshong central venous catheters utilizing fluoroscopic techniques. The interior cells of the spheroids showed a moderate, positive reaction with the beta 1 antibody but significantly reduced from that at the periphery. In the case of diagnostic selective nerve blocks used for evaluation of complex or protean nerve compression, surgical confirmation and clinical results should be a reliable gold standard.

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Both 5 alpha-NET and 3 beta,5 alpha-NET blocked the PR down-regulation induced by P4 as assessed by Western and Northern blot methods. Short-chain fatty acid production and fiber degradation by human colonic bacteria: effects of substrate and cell wall fractionation procedures. Random cytochrome-C-oxidase deficiency of oxyphil cell nodules in the parathyroid gland. Large differences in antigen expression were observed for the different cell lines.

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4 cats were given path-selection problems, with reference to the property of the correct path to lead to a visible goal. Detection of micronuclei, cell proliferation and hyperdiploidy in bladder epithelial cells of rats treated with o-phenylphenol. Focal ischemic necrosis of the liver associated with cirrhosis: radiologic findings. Tumor cell clusters, mixed-cell doublets (one cytokeratin-positive and -negative cell), and mixed-cell clusters were detected in 22 of 24 patients. The inhibitors affect phosphorylation and other partial reactions of the ATPase that depend on cytoplasmic conformational changes.

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A common anti-DNA idiotype in sera of patients with active pulmonary tuberculosis. Pregrowth in tetracycline did not enhance conjugation in Bacillus sphaericus x B.

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In ovariectomized rats, ALN both prevented and reversed the bone changes produced by estrogen deficiency at oral doses equivalent to 0.1 mg/kg per day or higher, and also maintained the mechanical strength of vertebrae. This review article investigates why the THR innovation process has failed. DTG depressed the excitatory responses of cells to both N-methyl-D-aspartate (NMDA) and quisqualate on a majority of the units tested, in no case causing an enhancement. Borreliae (0.25 micron in diameter) were found only in the lumen of the midgut. Frequent headaches were as common as in other population-based studies worldwide.

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DNA-index in combination with either the age of patients or the histological grade of tumours, enabled the separation of prognostically different subgroups. The indiscriminate use of anabolic-androgenic steroids has been shown to induce pathologic changes in the Achilles tendon in several situations. Interleukin-6 and the network of several cytokines in multiple myeloma: an overview of clinical and experimental data. Nucleotide sequence analysis of the RNA segment revealed that ts7 had four amino acid changes in the NA molecule but not in NB. To review the methods used in the many publications on the MRFIT screenees.

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Using the genomic DNA as template, the gene encoding nerve growth factor (beta-NGF) in the Chinese population was amplified using polymerase chain reaction (PCR). OBSERVATIONS ON SPECIFIC THERAPY OF MIXED EXPERIMENTAL INFECTION CAUSED BY CL. Functional differences among FimA variants of Porphyromonas gingivalis and their effects on adhesion to and invasion of human epithelial cells. This inhibition is greater in the wall than in the cytoplasmic fraction.

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In the white matter of the adult CNS, netrin-1 protein is absent from compact myelin but enriched in periaxonal myelin at the interface between axons and oligodendrocytes. It remains to be shown whether it may also have advantage in the long term. A case of an infant with a mediastinal neurenteric cyst is used to review this rare entity. The effects of nitroprusside (NP) on hemodynamics, especially on venous flow velocity of the inferior vena cava (IVC) were evaluated in 20 remote myocardial infarction patients. Mitotic index and cell proliferation kinetics for identification of antineoplastic activity.

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At the same time, scientists and regulators are concerned about the potential health and environmental risks related to the widespread production and use of the nanomaterials created by these technologies. During closure of the neural tube and for 2-4 hr thereafter, NCAM was expressed in a distinctive radial pattern in coronal sections of the neural tube. Statistical comparison was made between measured blood pressure (BP) from arterial line and calculated BP derived from ear pulse oximeter waveform in 10 patients undergoing coronary artery bypass graft surgery.

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After removal of the endothelium, contractile response to clonidine was poorer in the diabetic group than the control group. The aim of this study was to estimate the number of autoimmune pancreatitis (AIP) patients in Japan and evaluate the influence of steroid therapy on the course of diabetes mellitus (DM) in AIP. Agonist activity of sumatriptan and metergoline at the human 5-HT1D beta receptor: further evidence for a role of the 5-HT1D receptor in the action of sumatriptan.

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The alterations of plasma potassium in patients with severe acute head injury. Association of bluetongue virus gene segment 5 with neuroinvasiveness. The fraction A3 also induced both interleukin and tumor necrosis factor alpha. In keratoconus, EMMPRIN was found in all layers of cornea, especially in histopathologically altered areas. MOVEMENT OF ORGANIC SOLUTES IN THE SAUSAGE TREE KIGELIA AFRICANA.

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This finding suggests that the permissiveness of the ependymal cell is crucial to viral entry and that sequential infection of glial cells leads to the characteristic distribution of demyelination. Recordings were made from neurons in the lateral superior olive (LSO) or medial nucleus of the trapezoid body (MNTB) with glass micropipettes filled with 4 M potassium acetate. Pancreatic beta-cell secretion after oral glucose or intravenous glucagon stimulation was studied in newly diagnosed patients with non-insulin-dependent diabetes mellitus (NIDDM) before and after glycemic control by diet treatment alone. An 8 mU dose was selected for further study after 24 weeks, and continuous dosing at 8 mU in 15 patients has now exceeded 6 years.

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Treatment with nootropic agents should be initiated after meticulous establishment of the diagnosis of dementia and continued over the long-term, if their effectiveness is clinically manifest. Determination of the lactate concentration in plasma using L-lactate:ferricytochrome c-oxidoreductase and tetraxolium salt

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DENV-3 was detected and quantitated in 17 IgM-positive samples by both systems. Analysis of these genes suggests that plants require a basic set of four Dicer types which were present before the divergence of mono- and dicotyledonous plants ( approximately 200 million years ago), but after the divergence of plants from green algae. The current case is the first malignant insulinoma with hepatoid differentiation.

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A new ion exclusion HPLC procedure accomplished with a pulsed electrochemical detection for the determination of several common aliphatic acids is described. Intravenous magnesium sulfate after aneurysmal subarachnoid hemorrhage: a prospective randomized pilot study. Overexpression of the AF-1 domain of RARalpha or RARgamma was sufficient to decrease transcriptional activation of retinoid-dependent genes in keratinocytes. Oxitocin trough umbilical vein immediately after delivery was not useful to diminish blood loss, retained placenta or time of third stage of labour.

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After implantation and at 3-month outpatient visits, VA conduction and ability to initiate and sustain pacemaker circus movement tachycardia (PCMT) were systematically assessed noninvasively by testing the response of the pacemaker to asynchronous and single synchronized chest wall stimuli, muscle signals, and programmer pertubations. We have succeeded in demonstrating ATPase and DNA helicase activities in purified HPV E1, expressed in E. The role of covariation versus mechanism information in causal attribution.

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Therefore, both partial seizure and cluster of spasms seem to be part of the same critical manifestation. Cyclic AMP is a key regulator of melatonin production in the chick pineal gland. The argument is made that various design attributes frequently associated with methodological quality should be considered as important moderator variables and their influence on trial outcome should not be assumed a priori but rather examined empirically. This report indicates that the 99mtechnetium dimercaptosuccinic acid (DMSA) scan is a useful test in making this determination. Aggregation of the IgE receptor on rat basophilic leukemia (RBL-2H3) cells triggers increased hydrolysis of polyphosphoinositides (PI), secretion of arachidonic acid (AA) and its metabolites, and degranulation to release 5-hydroxytryptamine.

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The absolute risk of thrombotic stroke remains small for OC users, and the absolute risk is probably very small even for those taking OCs. Metabolism of the thyroid hormones with respect to cytoprotection.

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Irradiation of the epidermal cells with UV-B induced a release of soluble factors that amplified MnSOD activity in fibroblasts via a paracrine mechanism. Moreover, other important infectious pathogens, including bacteria, protozoa, and nonenveloped viruses, are not detected in current testing programs.

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Arsenic, drinking water, and health: a position paper of the American Council on Science and Health. Relationships among antibacterial activity, inhibition of DNA gyrase, and intracellular accumulation of 11 fluoroquinolones. The detection of a fetal electrocardiogram (FECG) is described to be a so-called inverse problem.

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Patients were divided into subgroups on the basis of maternal complications. This content of Ag-NOR per nucleus has a distinct difference in between NPC and benign lesion. Understanding the mechanisms involved in the crosstalk between inflammation and coagulation may yield new therapeutic strategies for human diseases. Dysfunction of the regulatory systems of the endothelium and its incapacity to efficiently deal with its physicochemical surrounding leads to disruption of endothelial integrity.

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To develop an assay to detect the family-specific mutation and apply the findings to genetic screening. Fixation-based surgery is a technique premised on using a fixation device, such as a fracture-fixation plate, during the alignment and distraction phases of an osteotomy. LAM makes a significant but weak contribution to the modulation of fat oxidation during submaximal exercise in obese men. Three patients with selective IgA deficiency were above 20 years of age. Using global gene-profiling methods, we studied the short-time CSA effect on the squamous cell line (SCC-015) using Affymetrix human gene chips (Human U133, 2.0 plus chip).

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The results showed that this gene encodes a protein that can transport UDP-galactose, but not CMP-sialic acid. Treatment modalities of psoriatics over a 6-year period (1975-1981). The main goal of this study was to identify the earliest time point of altered extracellular matrix protein gene expression by utilizing Northern blot analyses of rat lungs continuously exposed to 1.0 ppm ozone for 14 days. The treatment of rectal carcinoma is mainly determined by its local extension, which is difficult to assess before surgery. Agranulocytosis as a complication of mercazolyl therapy of toxic goiter patients

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The purpose of drug surveillance studies is to ascribe the adverse event observed to a pharmacological cause and to try to evaluate its frequency in order to draw reliable conclusions. The effects of quercetin on the mutagenicity of 2-acetylaminofluorene (AAF) and its 3 active metabolites, N-hydroxy-AAF (N-OH-AAF), aminofluorene (AF) and N-acetoxy-AAF(N-OAc-AAF) were investigated. The role of government agencies in the development of cancer policy. Spermine and spermidine are non-specific inhibitors of in vitro hematopoiesis.

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A voltage-gated calcium channel is linked to the antigen receptor in Jurkat T lymphocytes. However, evidence from other trials shows that the ergometrine component not uncommonly has side effects of nausea, vomiting, and raised blood pressure. The entire time course of changes in neutrophil count is more informative than a single measurement if myelosuppression is prolonged and at a level associated with increased incidence of clinical adverse effects. In this study, the cardiac circumference as measured in a four-chamber view was analyzed to determine its relationship to three linear, sonar measurements--biparietal diameter, femoral length, and abdominal circumference--and two sonographically derived fetal parameters--gestational age and estimated fetal weight. When two cells moving in opposite directions meet end to end, they transmit the C signal to each other and in response reverse their gliding direction.

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The clinical use of this drug in the treatment of epilepsy has been sporadically linked to the development of psychosis. It appears, therefore, that itraconazole, though not the final answer to management of deep mycoses, is certainly a major improvement on previous drugs. Frontal sinus mucocele: a rare complication of craniofacial fibrous dysplasia.

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Further, uPAR could be directly localized in caveolae by in vivo immunoelectron microscopy. In HeLa cells beta 1 integrin forms heterodimers with alpha 1, alpha 2, alpha 3, alpha 5 and alpha 6 integrin subunits. Recently we came across a severe anaphylactoid reaction, possibly as a result of administration of plaslloid in a patient who was undergoing elective surgery for cervical carcinoma.

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Linezolid is the first drug issued from the oxazolidinones, a novel class of antimicrobial agents with potent activity against gram-positive pathogens. Two ubiquitin ligases, the SKP1-CUL1-F-box-protein (SCF) complex and the anaphase-promoting complex/cyclosome (APC/C), are responsible for the specific ubiquitylation of many of these regulators. Education of patients with asthma is aimed at improving their knowledge, skills and attitudes, and thus compliance and control. DAF-16-dependent and independent expression targets of DAF-2 insulin receptor-like pathway in Caenorhabditis elegans include FKBPs. As conjugate these were applied anti-chicken IgY with horseradish peroxidase and ABTS with H2O2 as obtained.

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Diagnostic importance of angiotensin I converting enzyme (ACE) activity determination Similarities also exist among the structures in the interactions with this motif and its assembly into larger features of aggregation. Actr-Ib, Actr-II and Actr-IIb, Alk-1, and Smad proteins (Smads 1-5 and Smad8) in the septal region of the basal forebrain during mouse development. FEATURES OF THE METABOLIC ACTIVITY OF HISTONES IN RESTING AND DIVIDING LIVER CELLS Both of the mouse Polk and the human POLK genes have two AhR-binding sites in the promoter regions and the expression of the mouse Polk gene is indeed enhanced upon AhR-activation.

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The similarity of the cytopathology in FCH in vivo and in these transfected cells in vitro strongly implicates the large surface protein as the direct cause of this acute liver disease. These results suggest that ATase-repairable damage is involved in the induction of SCE, chromosome aberrations and micronuclei in V79 cells. Repair of distal tendo Achillis rupture with the use of the Mitek Anchor System. These results indicate that the occurrence and distribution of serum proteins in gliomas depend on the molecular weight of serum proteins, serum concentration and the differentiation of tumors. Retrospective review of serial duplex scans of the carotid bifurcation.

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The extent of this increase in the serum levels of fibrin degradation products correlated well with increased severity of the disease. Recent trends in drug therapy have attempted to refine the molecular and biological targets of therapy, based on the assumption that a single biological process or molecule is critical to restenosis. It is apparent that in all types of amyloid fibrils, three common features are displayed by the major protein constituents. Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor. Of these, 43 were from cats that had ORLs in other teeth (group A) and 13 were from cats with no clinical or radiographic evidence of ORLs in any teeth (group B).

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Cysteine-substituted proteins encoded by mutagenized genes may be screened directly for disulfide formation within oligomers or, alternatively, different pools of genes may be randomly recombined to generate gene populations with substitutions in multiple regions. These results suggest that a reduction of killing activity, either spontaneous or drug-induced, would contribute to the development of periodontal disease. In addition, the authors found normal sarcolemmal nNOS expression and a reduced expression of alpha-dystroglycan in muscle fibers. Selective attention was studied by registering cortical evoked potentials to acoustic stimuli in mental patients and mentally healthy subjects of old age.

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Both eyes of 11 patients with unilateral XFS and the unilateral eyes of 11 subjects without evidence of XFS were examined using UBM. Primiparous women in the UK sample showed highly elevated fear scores when compared with a Swedish sample. Vesicoureteral reflux was present in the moieties of ipsilateral duplicated kidney in 2 patients, and bilateral reimplantation was performed in 2 who had a history of contralateral vesicoureteral reflux that resolved. Micromechanical methods to determine haemorheological parameters.

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The phosphorylation pattern is affected by mutations in the SNF1-SSN6 pathway, which is involved in glucose repression-depression. Large receptor clusters were identified on muscle cells and their fate was followed afterward. Further research is needed to co to jest lansoprazole dosage examine the effectiveness and cost-effectiveness of the initiatives described. absorption at lambda max of 271 nm and shoulders at 261 and 281 nm. Patients in high- and very high-risk categories for cardiovascular disease, peripheral vascular disease/peripheral neuropathy, eye disease, and renal disease had markedly increased medical and pharmaceutical costs compared with those in low-risk categories.

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MRI with intravenous contrast has recently become the imaging modality of choice in the evaluation of patients developing recurrent back pain or volero cycling review symptoms following laminectomy and/or discectomy. Sorting of crypt cells based on staining with anti-beta1 integrin antibody produced a cell population with a significantly enhanced ability to form colonies.

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Hence, in a number of important pathogens, regulatory mutations that result in drug transporter overexpression and concomitant elevated antimicrobial resistance are often observed. To compare tissue specimens of canine abdominal organs collected by standard techniques (ST) and harmonic scalpel (HS) and to cyclophosphamide methotrexate 5 fluorouracil side effects determine the effect of each technique on wound healing. The nature of legal contracts, research protocols and consent forms for patients are discussed. These data demonstrate that chronic elevation of IL-6 in the CNS reduces body weight gain and visceral adiposity without affecting food intake.

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Determination of complement activating circulating immune complexes and an example for antigen specific immune complex assays. mollis-hybrid crosses showed homozygous resistance to all three isolates. bapex vs rolex This model permits evaluation of different therapeutical approaches for improving gas exchange during ARDS.

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There was no association between dietary intake and serum choline levels, nor could a relationship be found between serum choline levels and cognitive function. Encephalic sites are most frequent, with rare medullary sites, and double brain and cord locations are exceptional. Oxytocin-immunoreactive projections onto medullary adrenaline neurons. Characteristics of participants (persons and vehicles) and regular strength ibuprofen mg size the circumstances of road accidents are routinely collected by police and road authorities, whereas details of the injuries and medical care provided to casualties are collected by hospital and ambulance services. Screening for high- and low-risk human papillomavirus types in single routine cervical smears by non-isotopic in situ hybridization.

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Predictive diagnosis of familial adenomatous polyposis with linked DNA markers: population based study. Interestingly, Fas-negative (Hep 3B and PLC/PRF/5) hepatoma cells were shown to be more susceptible to apoptosis induced by 4HPR than were Fas-positive (Hep G2 and SK-HEP-1) hepatoma cells. Diesel engystol tablets dosis de diclofenaco exhaust particles enhance T-cell activation in severe asthmatics. Ischaemia-reperfusion injury following tourniquet release is a good in vivo model for evaluating acute conditions.

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Measuring health status over time is problematic when some subjects die, because death does not have a defined value on most health status measures. Eleven mutants were created in the cloned gene by site-directed mutagenesis to identify glucophage xr 750 mg uses the active site of this thiol endopeptidase.