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Coxib (Celecoxib)

Impact of Coxib on capecitabine tolerability and activity in pretreated metastatic breast cancer: results of a phase II study with biomarker evaluation. Coxib (Celebrex), a widely prescribed selective inhibitor of cyclooxygenase-2, can modulate ion channels independently of cyclooxygenase inhibition.

Other names for this medication:
Celecoxib, Celebrex, Artilog, Artose, Caditar, Celcox, Celcoxx, Celebra, Celeco, Celemax, Ciox, Colcibra, Coxib, Dilox, Dorex, Dorit, Flaxel, Impedil, Lexfin, Onsenal, Sionara, Solexa, Zycel,

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Coxib is used to relieve pain, tenderness, swelling and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints), rheumatoid arthritis (arthritis caused by swelling of the lining of the joints), and ankylosing spondylitis (arthritis that mainly affects the spine). It is also used to treat juvenile rheumatoid arthritis (a type of arthritis that affects children) in children 2 years of age and older. Coxib is also used to treat painful menstrual periods and to relieve other types of short-term pain including pain caused by injuries, surgery and other medical or dental procedures, or medical conditions that last for a limited time. Coxib is in a class of NSAIDs called COX-2 inhibitors. It works by stopping the body's production of a substance that causes pain and inflammation.

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An overview of Canadian privacy law for pharmaceutical and device manufacturers operating in Canada. The efficacy of music for the treatment of pain has not been established.

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After surgery, visual function was maintained with prolonged systemic therapy with fluconazole and methylprednisolone. To examine whether osteoblasts secrete colony-stimulating activity (CSA) in response to parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP), conditioned medium (CM) from ROS 17/2.8 cells and primary rat osteoblasts were examined for induction of clonal growth of cultured rat bone marrow cells.

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Automated flow injection spectrophotometric determination of zinc using zincon: applications to analysis of waters, alloys and insulin formulations. The plasma cholesterol-elevating effects of methionine, betaine and histidine were all prevented, more or less, by the concurrent addition of glycine to the diet, suggesting the existence of a common mechanism for their effects. Improved identification of details in double-contrast studies of the stomach using a new mixture of contrast media

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Thus, our results strongly suggest that generation of PCho by the PLD/choline kinase pathway is one of the critical steps in regulating cell growth in NIH 3T3 stimulated by growth factors. Increased LOX-1 protein expressions in cell lysates and cell culture medium were detectable as early as 4 h and peaked at 12 h after treatment with thrombin or factor Xa. Though a pressure sensation is a common complaint, significant ECG changes have not been reported after subcutaneous administration of sumatriptan.

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This same approach to bradyarrhythmias applies regardless of the anatomic and electrophysiologic etiology of the decreased heart rate. The existence of these hyperreactive CHC cleavage sites suggests that type I, II, and III collagens contain regions that have specific nontriple helical conformations. Birth cohort, time, and age effects in Italian cancer mortality.

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Melatonin influences the reproductive physiology of male pallid bats. Both the morphology of the type 2 pneumocytes and their expression of surfactant protein A were maintained for at least 6 days in vitro. Factors that determine the spectrum of target organs involved in autoimmune destruction are poorly understood. Macrophage infiltration-associated thymidine phosphorylase expression correlates with increased microvessel density and poor prognosis in astrocytic tumors.

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Nor did MAM treatment affect exploration in the elevated plus maze. This consensus is the result of a recent meeting to establish a better approach to these patients. Malignant melanoma and other second cutaneous malignancies in cutaneous T-cell lymphoma. These findings emphasize the role of the main olfactory system in the detection and the integration of the ram odor, and also suggest the participation of the accessory olfactory system.

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Blockade of angiotensin II type 1 receptors suppressed free radical production and preserved coronary endothelial function in the rabbit heart after myocardial infarction. Infusions of SKF-38393 into the frontal cortex, on the other hand, were ineffective in altering striatal ACh. Morphometric analysis of small intestinal specimens showed a significant decrease in villous length, villus-to-crypt ratio and mucosal complexity among iron deficient piglets. Difficulties in diagnosis are addressed, with reference in particular to the high incidence of depression in this group. Helicobacter pylori infection and nonsteroidal anti-inflammatory drug use are both common causes of peptic ulcer.

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A prospective randomized placebo controlled trial was performed to assess the immediate use of oral contraceptive (OC) on the amount of blood loss in the post-abortion period in women undergoing medical abortion by mifepristone and misoprostol. Thus, distinct pathogens establishing chronic infection in the face of strong humoral immune responses select antibodies along a common idiotypic axis of the immune network. A 2-year study of 250 eyelids has been done revealing no untoward effects or loss of pigmentation. An in vitro system for testing leucocyte and leukaemic cell line adhesion to synthetic fibres.

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Only limited information is available on effects of combinations of TLR agonists. The binding component of the cytosolic fraction was identified as a protein(s) because of its heat-lability and sensitivity to proteases. The results of preliminary studies on penetration of the selected biologically-active components of pesticides (dichlorvos, 2,4-D, cypermethrin, carbofuran) through the selected protective materials (fabric coated with viton and butyl on both sides, rubberised fabric, butyl rubber) are presented.

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The patient was not receiving any drugs known to cause stuttering, and it is postulated that the stutter developed as a result of the gross impairment of brain function secondary to chronic starvation. 30 minutes before and 90 and 210 minutes after the cisplatin injection. Representatives of several currently available spiroplasma serovars were used in feeding and injection experiments involving Drosophila pseudoobscura adult flies in order to evaluate the host-range of the spiroplasmas and to determine their pathogenicity for flies. In the present study we aimed to investigate the inhibitory effect of PGA1 on platelet function.

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A mouth speculum for orogastric administration of compounds to nonhuman primates is described here. Except for a possible influence of a disturbed calcium metabolism other pathogenetic factors supposed in literature could not be found. Long-term culture of the rat medial aorta with preservation of the characteristic properties of differentiated smooth muscle vascular cells The conclusion may offer an explanation for the contradictory results found in the literature of the cytological effect of oral contraceptives, although the major chemical constitution of all contraceptives used is the same, still there are minor differences in their chemical structure.

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The decreased hydroxyproline content in the arterial walls remained low after rats were refed the standard diet for 4 weeks. Despite the limitations of this cross-sectional self-report study, it identifies attitudes and knowledge as potential targets for intervention with middle-aged women. Cognitive impairment in community-dwelling older Nigerians: clinical correlates and stability of diagnosis. Recent studies on growth factors related with some of the factors previously mentioned and expression of oncogenes complete the overview of the methods involved in the search for prognostic data.

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The data were then searched retrospectively to describe the development of these patterns of ability from the very beginnings of reading acquisition. Asymmetrical localization of Tc-99m Sn F2 colloid labeled white cells in the bony pelvis after radiotherapy.

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A retrospective study of squamous-cell carcinoma of the supraglottic larynx. Early bystander cardiopulmonary resuscitation is the most important factor for survival after submersion. The Mediterranean region has been characterised by a number of pre-historical and historical demographic events whose legacy on the current genetic landscape is still a matter of debate. In aqueous media, approximate rate constants for the reactions between hydroxyl radicals (.OH) and biphenyl compounds such as dehydrodieugenol, magnolol, honokiol, dehydrodidihydroeugenol, dehydrodivanillyl alcohol, and dehydrodicreosol were estimated by competition reactions for .OH between these biphenyls and 5,5-dimethyl-1-pyrroline-N-oxide (DMPO).

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In conclusion, it was suggested that ovarian parthenogenesis in mice occurs most frequently when eggs with genetically susceptible nature, were exposed to the microenvironment produced by the abnormal follicles, and these parthenotes adhere to the ovarian tissues and differentiate three germ layers by some roles of corpora lutea and undergo teratocarcinogenesis. During fatigue the high frequency and intermediate frequency rate constants declined, but the low frequency rate constant remained unchanged.

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Intra-articular treatment of inflammatory arthritis: double-blind trial comparing bufexamac with methylprednisolone acetate. The maximal hyperfine splitting was determined and the empirical correlation time calculated.

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Since they were found to be of equal predictive value, one marker might well serve as a substitute for another. Here we report, for the first time, the expression of a functional CXCR4 in primary human normal bronchial epithelial cells and the regulation of CXCR4 gene expression by proinflammatory mediators. The study of the mitotic index in CHO and HeLa cells treated with this compound showed that it may be a cytostatic drug. The influence of fluoride emissions from a modern aluminum smelter on concentrations of skeletal fluoride and dental fluorosis in a resident population of white-tailed deer was studied. The prolactin responses to NMA and kainate changed with the reproductive state of the animal and the site of administration.

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We extended these observations to examine the interaction between the RAD51B/RAD51C complex and the other RAD51 paralogs. Decrease in arachidonoyl-containing phosphatidylinositols in pancreas of rats fed an ethanol-containing diet. A significant increase in plasma aldosterone was observed 30 min after the start of the angiotensin II infusion.

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Furthermore, GLP-1 receptor knockout mice (GLP-1R(-/-)) were completely insensitive to the antidiabetic actions of OFS. Superoxide production of neutrophils relatively decreased during CPB and significantly increased after CPB in the control group. Separations in excess of 600 mum have been observed between Bacillus anthracis Sterne strain and its genetic relative, Bacillus thuringiensis.

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Ultrastructural effects of cellulose biosynthesis inhibitor herbicides on developing cotton fibers. The effect of time of day on levels of hypothalamic proopiomelanocortin primary transcript, processing intermediate and messenger ribonucleic acid in proestrous and estrous rats. Eleven Alternaria alternata strains isolated from Red Delicious apples in cold storage in Argentina, were tested for alternariol and alternariol methyl ether production in laboratory media and in whole fresh fruits. Recommended methods for locating the capsules include plain film radiography and ultrasound imaging.

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A hemostat is placed on the stump of the severed medial rectus muscle for traction purposes, and long, minimally curved scissors are used to cut the optic nerve near the orbital apex. Additional studies of mice deleted of B7.1, B7.2, and CTLA-4 suggest that the enhanced response induced by rmB7.2-Ig may not be mediated through CD28 ligation alone. It is important, therefore, to recognize balanitis of Zoon as a nonspecific pattern that may occur either as an isolated finding or may complicate other diseases affecting the glans penis or prepuce of uncircumcised men.

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The relationship between tangle and plaque formation during healthy aging and mild dementia. Three of the identified antigens were shown by quantitative enzyme-linked immunosorbent assay tests on various human tissues to be specifically expressed in the brain. We simultaneously determined the physical structure and optical transition energies of individual single-walled carbon nanotubes by combining electron diffraction with Rayleigh scattering spectroscopy. Specialized anatomic and physiological features of the cerebrovasculature and cerebral tissue fluids result in barriers which significantly restrict delivery of a wide range of possible therapeutic agents.

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The aim of this fMRI study was to identify and differentiate brainstem and cerebellar areas involved in horizontal and vertical OKN (h/vOKN) in humans. One patient was admitted twice, accounting for 31 sets of blood specimens. MR fluoroscopy may become a tool of great clinical value, providing much important information for disease evaluation and treatment selection.

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Groups of rats were infected with 2000 normal larvae of Nippostrongylus brasiliensis or larvae irradiated with 10 to 120 kR. These differences were consistent with the emphasis on an inpatient setting for IM residents and on office-based care for FP residents. Ethylene production from peptides and protein containing methionine.

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Kinetic assays show that HS reduces the cysteine proteinase inhibitory activity (K(i app)) of HK about 10-fold. An approach to calibration of membrane extraction with a sorbent interface.

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Information on incidence trends for myocardial infarction (MI) could be used to distinguish between these 2 possibilities. We report the case of an exceptional association of ulcerative colitis with lichen planus in a 40-year old woman with a 2 year history of ulcerative colitis, who had lesions on the buccal mucosa and the lower lip for which the diagnosis of lichen planus was made and confirmed histologically. Detection of IL-1 beta, TNF-alpha, and IL-6 gene transcription by the polymerase chain reaction in keratinocytes, Langerhans cells and peritoneal exudate cells during infection with herpes simplex virus-1. An essential feature of this method is the slight surgical injury. At the metabolic level, we describe the specific accumulation of several phenylpropanoid-polyamine conjugates in MJ-treated BY-2 cells.

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The findings of this study support a model of nonuniform changes in airspace dimensions associated with in vivo inflation and deflation of the lungs. The current study was performed to evaluate the effect of melatonin on the survival time in patients with brain metastases due to solid neoplasms. Crystallization and preliminary crystallographic analysis of sfericase. The other group of stained neurons were in the ventral cluster, a group comprised of a small number of large neurons, many of which are motor neurons that innervate the buccal muscles involved in producing biting and swallowing movements.

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The Radiation Therapy Oncology Group (RTOG) began participating in this program in 1976. We also consider the developments in modern biology that may provide input to therapy planning. Growth processes in teeth distinguish modern humans from Homo erectus and earlier hominins. These results indicate that changes associated with protein kinase activity in the brain following an ischemic insult may have profound effects upon neurodegeneration and neuronal survival. The foamy cells were positive for CD-68 and vimentin and negative for cytokeratin and S-100.

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CD4 and CD25 monoclonal antibody cocktail in kidney transplant rejection prophylaxis: clinical results of a pilot study. Using an isogenic system, we have determined the impact that the four promoters known to control bla(TEM) gene expression have on beta-lactamase activity.

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We report a case of solitary rectal ulcer (SRU) in a patient who had been previously diagnosed of granulomatous appendicitis. Keratinocyte growth factor is a bifunctional regulator of HPV16 DNA-immortalized cervical epithelial cells. A relationship was found between differences in the weight and the linear dimensions of the cerebellum and differences in skull size.

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Word intelligibility decrements and the comprehension of time-compressed speech. In this study, we evaluated the antinociceptive effects and durations of action of three novel depots of buprenorphine esters buprenorphine propionate, enanthate, and decanoate given by IM injection, in rats.

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Stress effects are also dependent on the tissue origin of lymphocytes, and they seem to be exclusively mediated by adrenal hormones. Baclofen (100 microM) suppressed the release of calcitonin gene-related peptide-like immunoreactivity evoked by electrical field stimulation from the dorsal half of the rat spinal cord.

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Peripheral-type benzodiazepine receptors in blood cells of anxious patients. Symptomatic hypotension induced by nifedipine in the acute treatment of severe hypertension. Incidence and short-term outcome of children with symptomatic presentation of organic acid and fatty acid oxidation disorders in Germany. This suggests that quality of life of caregivers could be improved even with burden in their lives and that the overwhelming focus in caregiving research on burden should be supplemented with an emphasis on quality of life.

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This article presents the first reported case of necrotizing fasciitis after postpartum tubal ligation performed through an infraumbilical incision. The one-way analysis of variance was applied and it was found that there was a highly significant difference in the frequency of sister chromatid exchanges in these patients before surgery, one month after surgical removal of cancerous tissue, and after three years as a follow-up study.

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A 48-year-old woman developed fever and malaise five days after being bitten by a pet rat. Computed tomography and conventional radiographs of the craniocervical region in rheumatoid arthritis. They were randomly assigned to an eight-day treatment with ivermectin as a single dose of 12 mg on day 1 followed by placebo for the remaining seven days, or DEC, total dose 1.3 g, or placebo, and ophthalmological review was undertaken over a period of one year.

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Risk assessment provides a useful foundation for understanding the environmental benefits, residual hazards, and engineering limitations of different remedy alternatives and for identifying or ranking management options. Therefore, when inadequate margins are expected, patients are better treated with full-dose radiotherapy from the start.

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Fiber projections to the median eminence included presumptive pathways similar to those previously described in other species. These results are consistent with a model of memory formation, in which dunce is hypothesized to disrupt acquisition and/or short-term memory.

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The order of potencies of adrenergic agonists was different for muscular and nerve-mediated effects, being clonidine greater than noradrenaline greater than methoxamine greater than isoprenaline for the inhibition of peristalsis and isoprenaline greater than noradrenaline greater than methoxamine greater than clonidine for the relaxation of circular muscle. The enzyme is a hexamer made of probenecid indian brands for atorvastatin identical subunits with a novel mononucleotide binding fold. In addition, a number of the 5-HT/GAD-containing neurons were retrogradely labelled with Fast blue dye that had been injected into the thoracic spinal cord. Sympathetic nervous system sensitivity to hemorrhagic hypotension in the subhuman primate.

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Bicoronal skin incision was combined with an additional linear one on the midline gabapentin 900 mg dose (T-shaped incision). The pseudorabies virus VP22 homologue (UL49) is dispensable for virus growth in vitro and has no effect on virulence and neuronal spread in rodents.

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CATSPER1 transcript losartan valsartan telmisartan irbesartan eprosartan brand was detected in both human testis and each human ejaculated semen sample. Immunohistochemical profile and chromosomal imbalances in papillary tumours of the pineal region. Total regression of AK-5 histiocytoma was obtained after injection of daunomycin-MAb conjugate into tumor bearing animals suggesting the specific targeting of the antineoplastic drug to the tumor. There was, however, no obvious alteration in proteasome function. Much texture information seems to be contained in MR images, which may prove useful for classification and image segmentation.

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ON relaxyl ingredients in red THE MECHANISM OF DEOXYRIBONUCLEATE INTEGRATION IN PNEUMOCOCCAL TRANSFORMATION. We describe the results of the topochemical polymerization of p-xylylenediammonium disorbate as the bifunctional monomer in the crystalline state via a radical chain polymerization mechanism. Diversity of clinical symptoms in A3243G mitochondrial DNA mutation (MELAS syndrome mutation). Validity and reliability of a modified version of the neck disability index. STUDIES OF THE EFFECT OF WEIGHT LOSS ON THE FAT AND LEAN BODY MASS.

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Possible mechanisms for these different response properties are discussed. Use of angiotensin-converting-enzyme inhibitors for diagnosing renovascular hypertension. Long term adaptation of a microbial population to a permanent metabolic constraint: overcoming thymineless death by losan pharma logo experimental evolution of Escherichia coli. Although depletion of 53BP1 resulted in checkpoint defects in mammalian cells, DT40 53BP1(-/-) cells had normal intra S phase and G2/M checkpoints.

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These results show that TH protein turnover in the mesoamygdaloid neurons can be reduced by chronic imipramine treatments, thereby producing an accumulation of inactive TH protein in the neurons while also sumatriptan nasal spray shortage of truck decreasing TH gene activity in the cell bodies. Liquid chromatographic mass spectrometric methods for the determination of marine polyether toxins. In both humans and rodents the occurrence and severity of obesity-associated non-insulin dependent diabetes mellitus (NIDDM) may be influenced by both gonadal hormones and genetic background.

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6R-L-erythro-5,6,7,8-tetrahydrobiopterin (R-THBP, SUN 0588) acts on the brain muscarinic and nicotinic cholinergic receptors as evaluated by positron emission tomography (PET) in rhesus monkey. PGE2 release from bladder strips was significantly higher in SCI rats than in control rats. Our results support the concept of DEBs as an effective way to deliver drugs to tumor. Cellular protein receptors of maculosin, a host specific phytotoxin of spotted knapweed (Centaurea maculosa L.). One-pot synthetic method of unsymmetrical diorganyl selenides: reaction of diphenyl furosemide drug book diselenide with alkyl halides in the presence of lanthanum metal.

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Clinical applications of the supraceliac aorta: anatomical and pathologic observations. Fetal and neonatal transfusion therapy, pre-term delivery, and intensive phototherapy avoid or greatly reduce the incidence of lavestra 50 mg tablettasche these complications. The mechanism by which Hoxa10 induces endometrial development to a state of receptivity is unknown as HOXA10-deficient endometrium appears histologically normal. An unusual case of acute postoperative monolateral renal insufficiency The effect of U(L)13 kinase appears to be specific inasmuch as it did not affect the accumulation of glycoprotein D in cells doubly infected by recombinant baculoviruses expressing these genes.

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The eye was sumatriptan generic manufacturers of lamotrigine infected in the retina in contrast to the cornea which was the site of infection in the original host. These data were obtained either directly from the IAM-ACHT chromatogram or from the chromatogram produced by a coupled column system.

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